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TM55B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q86T03 |
| Other Accession | Q5PPM8, Q3TWL2, Q4R6W2, NP_001094284.1, NP_653169.2 |
| Reactivity | Human |
| Predicted | Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29470 Da |
| Antigen Region | 183-211 aa |
| Gene ID | 90809 |
|---|---|
| Other Names | Type 1 phosphatidylinositol 4, 5-bisphosphate 4-phosphatase, Type 1 PtdIns-4, 5-P2 4-Ptase, PtdIns-4, 5-P2 4-Ptase I, Transmembrane protein 55B, TMEM55B, C14orf9 |
| Target/Specificity | This TM55B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human TM55B. |
| Dilution | FC~~1:10~50 IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TM55B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIP4P1 (HGNC:19299) |
|---|---|
| Function | Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid- dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). |
| Cellular Location | Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein |
| Tissue Location | Ubiquitous.. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).
References
Zou, J., et al. Proc. Natl. Acad. Sci. U.S.A. 104(43):16834-16839(2007)
Ungewickell, A., et al. Proc. Natl. Acad. Sci. U.S.A. 102(52):18854-18859(2005)
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$ 150.00
$ 385.00
Cat# AP13171b
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