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SLC16A10 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q8TF71 |
| Other Accession | NP_061063.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55493 Da |
| Antigen Region | 301-329 aa |
| Gene ID | 117247 |
|---|---|
| Other Names | Monocarboxylate transporter 10, MCT 10, Aromatic amino acid transporter 1, Solute carrier family 16 member 10, T-type amino acid transporter 1, SLC16A10, MCT10, TAT1 |
| Target/Specificity | This SLC16A10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-329 amino acids from the C-terminal region of human SLC16A10. |
| Dilution | WB~~1:2000 FC~~1:10~50 IHC-P~~1:25 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC16A10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A10 |
|---|---|
| Synonyms | MCT10, TAT1 {ECO:0000303|PubMed:11827462 |
| Function | Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4- dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91Y77}; Multi-pass membrane protein |
| Tissue Location | Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.
References
Loubiere, L.S., et al. Placenta 31(4):295-304(2010)
Friesema, E.C., et al. Mol. Endocrinol. 22(6):1357-1369(2008)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Park, S.Y., et al. Arch. Pharm. Res. 28(4):421-432(2005)
Halestrap, A.P., et al. Pflugers Arch. 447(5):619-628(2004)
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