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TMEM203 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q969S6 |
| Other Accession | NP_444273.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15760 Da |
| Antigen Region | 89-117 aa |
| Gene ID | 94107 |
|---|---|
| Other Names | Transmembrane protein 203, TMEM203 |
| Target/Specificity | This TMEM203 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the C-terminal region of human TMEM203. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMEM203 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM203 |
|---|---|
| Function | Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Acts as a regulator of STING-mediated inflammatory signaling in macrophages (PubMed:31346090). Forms a complex with STING, promoting the activity of TBK1 kinase and the transcription factor IRF3, leading to activation of type I interferon expression (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q8R235}. Lysosome membrane {ECO:0000250|UniProtKB:Q8R235}; Multi-pass membrane protein. Note=Co-localizes with STING1 in the lysosome membrane, mediates lysosomal localization of STING1 {ECO:0000250|UniProtKB:Q8R235} |
| Tissue Location | Increased expression seen in T-lymphocytes from patients with systemic lupus erythematosus (SLE) |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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$ 365.00
$ 140.00
Cat# AP13264b
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