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TRIM54 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9BYV2 |
| Other Accession | Q58D15, NP_912730.2, NP_115935.3 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40301 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 57159 |
|---|---|
| Other Names | Tripartite motif-containing protein 54, Muscle-specific RING finger protein, MuRF, Muscle-specific RING finger protein 3, MuRF-3, MuRF3, RING finger protein 30, TRIM54, MURF, MURF3, RNF30 |
| Target/Specificity | This TRIM54 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIM54. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM54 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM54 |
|---|---|
| Synonyms | MURF, MURF3, RNF30 |
| Function | May bind and stabilize microtubules during myotubes formation. |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). |
| Tissue Location | Specifically expressed in heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
References
Centner, T., et al. J. Mol. Biol. 306(4):717-726(2001)
Spencer, J.A., et al. J. Cell Biol. 150(4):771-784(2000)
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