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TRIM62 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BVG3 |
| Other Accession | Q80V85, NP_060677.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54268 Da |
| Antigen Region | 308-337 aa |
| Gene ID | 55223 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM62, 632-, Tripartite motif-containing protein 62, TRIM62 |
| Target/Specificity | This TRIM62 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human TRIM62. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM62 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM62 {ECO:0000303|PubMed:23402750, ECO:0000312|HGNC:HGNC:25574} |
|---|---|
| Function | E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C- type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750). |
| Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press : Lott, S.T., et al. PLoS Med. 6 (5), E1000068 (2009) : Muthuswamy, S.K. PLoS Med. 6 (5), E1000073 (2009) : Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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