P11 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P21128 |
Other Accession | NP_001165910.1, NP_001165911.1, NP_006016.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 46872 Da |
Antigen Region | 2-32 aa |
Gene ID | 8909 |
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Other Names | Poly(U)-specific endoribonuclease, 31--, Placental protein 11, PP11, Protein endoU, Uridylate-specific endoribonuclease, ENDOU |
Target/Specificity | This P11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human P11. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | P11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ENDOU |
---|---|
Function | Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. |
Cellular Location | Secreted. |
Tissue Location | Placental-specific, but also associated with various malignant neoplasms |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Laneve, P., et al. J. Biol. Chem. 283(50):34712-34719(2008)
Gioia, U., et al. J. Biol. Chem. 280(19):18996-19002(2005)
Jenne, D. Biochem. Biophys. Res. Commun. 176(3):1000-1006(1991)
Grundmann, U., et al. DNA Cell Biol. 9(4):243-250(1990)
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