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CRKL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P46109 |
| Other Accession | Q5U2U2, P47941, NP_005198.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33777 Da |
| Antigen Region | 50-79 aa |
| Gene ID | 1399 |
|---|---|
| Other Names | Crk-like protein, CRKL |
| Target/Specificity | This CRKL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CRKL. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRKL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRKL |
|---|---|
| Function | May mediate the transduction of intracellular signals. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, Y.H., et al. Oncogene 29(10):1421-1430(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Segovis, C.M., et al. J. Immunol. 182(11):6933-6942(2009)
Seo, J.H., et al. Mol. Cell. Biol. 29(11):3076-3087(2009)
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