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CORO2A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92828 |
| Other Accession | NP_438171.1, NP_003380.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59763 Da |
| Antigen Region | 185-213 aa |
| Gene ID | 7464 |
|---|---|
| Other Names | Coronin-2A, IR10, WD repeat-containing protein 2, CORO2A, IR10, WDR2 |
| Target/Specificity | This CORO2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human CORO2A. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CORO2A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CORO2A |
|---|---|
| Synonyms | IR10, WDR2 |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants.
References
Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)
Marshall, T.W., et al. J. Cell. Sci. 122 (PT 17), 3061-3069 (2009) :
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Yoon, H.G., et al. Mol. Cell 12(3):723-734(2003)
Yoon, H.G., et al. EMBO J. 22(6):1336-1346(2003)
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