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NKD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q969G9 |
| Other Accession | NP_149110.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52285 Da |
| Antigen Region | 83-111 aa |
| Gene ID | 85407 |
|---|---|
| Other Names | Protein naked cuticle homolog 1, Naked-1, hNkd, hNkd1, NKD1, NKD |
| Target/Specificity | This NKD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the N-terminal region of human NKD1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NKD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKD1 |
|---|---|
| Synonyms | NKD |
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. |
| Cellular Location | Cell membrane. Cytoplasm |
| Tissue Location | Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
References
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) : Creyghton, M.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5397-5402(2006) Creyghton, M.P., et al. Genes Dev. 19(3):376-386(2005) Yan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14973-14978(2001) Katoh, M. Int. J. Oncol. 19(5):963-969(2001)
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