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Mouse Adrbk1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99MK8 |
| Other Accession | P26817, P25098, P21146 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 79639 Da |
| Antigen Region | 645-674 aa |
| Gene ID | 110355 |
|---|---|
| Other Names | Beta-adrenergic receptor kinase 1, Beta-ARK-1, G-protein-coupled receptor kinase 2, Adrbk1, Grk2 |
| Target/Specificity | This Mouse Adrbk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 645-674 amino acids from the C-terminal region of mouse Adrbk1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Adrbk1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Grk2 {ECO:0000312|MGI:MGI:87940} |
|---|---|
| Synonyms | Adrbk1 |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P26817}. Cell membrane {ECO:0000250|UniProtKB:P21146}. Postsynapse {ECO:0000250|UniProtKB:P26817}. Presynapse {ECO:0000250|UniProtKB:P26817} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.
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$ 365.00
$ 140.00
Cat# AP13797b
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