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DGCR14 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96DF8 |
| Other Accession | NP_073210.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52568 Da |
| Antigen Region | 217-244 aa |
| Gene ID | 8220 |
|---|---|
| Other Names | Protein DGCR14, DiGeorge syndrome critical region 13, DiGeorge syndrome critical region 14, DiGeorge syndrome protein H, DGS-H, Protein ES2, DGCR14, DGCR13, DGSH, DGSI, ES2 |
| Target/Specificity | This DGCR14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the Central region of human DGCR14. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DGCR14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ESS2 (HGNC:16817) |
|---|---|
| Function | May be involved in pre-mRNA splicing. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P34420}. |
| Tissue Location | Highly expressed in heart, brain and skeletal muscle. Detected at low levels in placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.
References
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Wang, H., et al. J Neural Transm 113(10):1551-1561(2006)
Jurica, M.S., et al. RNA 8(4):426-439(2002)
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