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TSNAX Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q99598 |
| Other Accession | Q9JHB5, Q9QZE7, Q4R599, NP_005990.1 |
| Reactivity | Human |
| Predicted | Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33112 Da |
| Antigen Region | 34-62 aa |
| Gene ID | 7257 |
|---|---|
| Other Names | Translin-associated protein X, Translin-associated factor X, TSNAX, TRAX |
| Target/Specificity | This TSNAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-62 amino acids from the N-terminal region of human TSNAX. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSNAX Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSNAX |
|---|---|
| Synonyms | TRAX |
| Function | Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. |
| Cellular Location | Cytoplasm, perinuclear region. Golgi apparatus. Nucleus. Note=Accumulate in the Golgi complex of mid- late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
References
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Schosser, A., et al. Mol. Psychiatry 15(8):844-849(2010)
Okuda, A., et al. Neuromolecular Med. 12(1):78-85(2010)
Nakata, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15873-15878(2009)
Palo, O.M., et al. Hum. Mol. Genet. 16(20):2517-2528(2007)
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