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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > VASH2 Antibody (C-term)
VASH2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q86V25 |
| Other Accession | Q8C5G2, NP_001129946.1, NP_079025.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40450 Da |
| Antigen Region | 216-245 aa |
| Gene ID | 79805 |
|---|---|
| Other Names | Vasohibin-2, Vasohibin-like protein, VASH2, VASHL |
| Target/Specificity | This VASH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the C-terminal region of human VASH2. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VASH2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VASH2 (HGNC:25723) |
|---|---|
| Synonyms | VASHL |
| Function | Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). |
| Cellular Location | Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). Associates with microtubules (PubMed:31235911) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
VASH2 is a angiogenesis inhibitor. It inhibits network formation by endothelial cells.
References
Kimura, H., et al. Blood 113(19):4810-4818(2009)
Shibuya, T., et al. Arterioscler. Thromb. Vasc. Biol. 26(5):1051-1057(2006)
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$ 150.00
$ 385.00
Cat# AP13956b
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