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TNFSF13B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y275 |
| Other Accession | NP_006564.1, NP_001139117.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31223 Da |
| Antigen Region | 16-44 aa |
| Gene ID | 10673 |
|---|---|
| Other Names | Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD257, Tumor necrosis factor ligand superfamily member 13b, membrane form, Tumor necrosis factor ligand superfamily member 13b, soluble form, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4 |
| Target/Specificity | This TNFSF13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-44 amino acids from the N-terminal region of human TNFSF13B. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNFSF13B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFSF13B |
|---|---|
| Synonyms | BAFF, BLYS, TALL1, TNFSF20, ZTNF4 |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B- cells and the B-cell response. |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
References
Zhang, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18956-18960(2010)
Molica, S., et al. Eur. J. Haematol. 85(4):314-320(2010)
Liu, J.Q., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(3):690-693(2010)
Onda, K., et al. Int. J. Hematol. 91(5):808-819(2010)
Hayashi, E.A., et al. J. Immunol. 184(9):4662-4672(2010)
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