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PDIA2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13087 |
| Other Accession | NP_006840.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58206 Da |
| Antigen Region | 210-239 aa |
| Gene ID | 64714 |
|---|---|
| Other Names | Protein disulfide-isomerase A2, Pancreas-specific protein disulfide isomerase, PDIp, PDIA2, PDIP |
| Target/Specificity | This PDIA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from the Central region of human PDIA2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDIA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDIA2 |
|---|---|
| Synonyms | PDIP |
| Function | Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. |
| Cellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE- ProRule:PRU10138} |
| Tissue Location | Highly expressed in pancreas (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 [PubMed 8561901]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Swiatkowska, M., et al. J. Biol. Chem. 285(39):29874-29883(2010)
Wang, C., et al. J. Biol. Chem. 285(35):26788-26797(2010)
Honjo, Y., et al. Brain Res. 1349, 90-96 (2010) :
Popescu, N.I., et al. Blood 116(6):993-1001(2010)
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