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NPPC Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P23582 |
| Other Accession | NP_077720.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 13246 Da |
| Antigen Region | 80-109 aa |
| Gene ID | 4880 |
|---|---|
| Other Names | C-type natriuretic peptide, CNP-22, CNP-29, CNP-53, NPPC, CNP2 |
| Target/Specificity | This NPPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids from the C-terminal region of human NPPC. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NPPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPPC |
|---|---|
| Synonyms | CNP2 |
| Function | [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed:1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034). Binds the clearance receptor NPR3 (PubMed:11533490). |
| Cellular Location | Secreted. |
| Tissue Location | [CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP; MIM 108780), brain natriuretic peptide (BNP; MIM 600295), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.
References
Lippert, S.K., et al. J. Immunol. Methods 362 (1-2), 32-37 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Wang, Y., et al. J. Cardiovasc. Pharmacol. 55(1):62-66(2010)
Cammarata, P.R., et al. Mol. Vis. 16, 630-638 (2010) :
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