NRD1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O43847 |
Other Accession | NP_001095132.1, NP_002516.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 131701 Da |
Antigen Region | 333-361 aa |
Gene ID | 4898 |
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Other Names | Nardilysin, N-arginine dibasic convertase, NRD convertase, NRD-C, NRD1 |
Target/Specificity | This NRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-361 amino acids from the Central region of human NRD1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NRD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NRDC (HGNC:7995) |
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Synonyms | NRD1 |
Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). |
Cellular Location | Mitochondrion. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHG1} |
Tissue Location | Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
NRD1 cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
References
Korovkina, V.P., et al. Am. J. Physiol., Cell Physiol. 296 (3), C433-C440 (2009) :
Hiraoka, Y., et al. Biochem. Biophys. Res. Commun. 370(1):154-158(2008)
Bernstein, H.G., et al. Neuroscience 146(4):1513-1523(2007)
Nishi, E., et al. J. Biol. Chem. 281(41):31164-31172(2006)
Hospital, V., et al. Protein Pept. Lett. 11(5):501-508(2004)
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