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NRD1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43847 |
| Other Accession | NP_001095132.1, NP_002516.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 131701 Da |
| Antigen Region | 333-361 aa |
| Gene ID | 4898 |
|---|---|
| Other Names | Nardilysin, N-arginine dibasic convertase, NRD convertase, NRD-C, NRD1 |
| Target/Specificity | This NRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-361 amino acids from the Central region of human NRD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NRD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRDC (HGNC:7995) |
|---|---|
| Synonyms | NRD1 |
| Function | Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). |
| Cellular Location | Mitochondrion. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHG1} |
| Tissue Location | Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NRD1 cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
References
Korovkina, V.P., et al. Am. J. Physiol., Cell Physiol. 296 (3), C433-C440 (2009) :
Hiraoka, Y., et al. Biochem. Biophys. Res. Commun. 370(1):154-158(2008)
Bernstein, H.G., et al. Neuroscience 146(4):1513-1523(2007)
Nishi, E., et al. J. Biol. Chem. 281(41):31164-31172(2006)
Hospital, V., et al. Protein Pept. Lett. 11(5):501-508(2004)
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