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CSTF3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q12996 |
| Other Accession | Q99LI7, NP_001317.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 82922 Da |
| Antigen Region | 556-585 aa |
| Gene ID | 1479 |
|---|---|
| Other Names | Cleavage stimulation factor subunit 3, CF-1 77 kDa subunit, Cleavage stimulation factor 77 kDa subunit, CSTF 77 kDa subunit, CstF-77, CSTF3 |
| Target/Specificity | This CSTF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 556-585 amino acids from the C-terminal region of human CSTF3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CSTF3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CSTF3 |
|---|---|
| Function | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
Hockert, J.A., et al. J. Biol. Chem. 285(1):695-704(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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