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SEC22B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O75396 |
| Other Accession | Q4KM74, O08547, O08595, NP_004883.2 |
| Reactivity | Human |
| Predicted | Hamster, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24741 Da |
| Antigen Region | 75-104 aa |
| Gene ID | 9554 |
|---|---|
| Other Names | Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, ERS-24, ERS24, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, SEC22B, SEC22L1 |
| Target/Specificity | This SEC22B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human SEC22B. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC22B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC22B |
|---|---|
| Synonyms | SEC22L1 |
| Function | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74} Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}. Melanosome. Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) {ECO:0000250|UniProtKB:Q4KM74, ECO:0000269|PubMed:17081065} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
Okumura, A.J., et al. J. Biol. Chem. 281(7):4495-4506(2006)
Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)
Nakajima, K., et al. EMBO J. 23(16):3216-3226(2004)
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