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SYT5 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O00445 |
| Other Accession | NP_003171.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42900 Da |
| Antigen Region | 138-167 aa |
| Gene ID | 6861 |
|---|---|
| Other Names | Synaptotagmin-5, Synaptotagmin V, SytV, SYT5 |
| Target/Specificity | This SYT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human SYT5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYT5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYT5 |
|---|---|
| Function | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SYT5 may be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
References
Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :
Sreenath, A.S., et al. Clin. Biochem. 38(5):436-443(2005)
Mizutani, A., et al. J. Biol. Chem. 275(13):9823-9831(2000)
Craxton, M., et al. FEBS Lett. 460(3):417-422(1999)
Fukuda, M., et al. J. Biol. Chem. 274(44):31421-31427(1999)
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