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GPR15 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P49685 |
| Other Accession | NP_005281.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40787 Da |
| Antigen Region | 331-360 aa |
| Gene ID | 2838 |
|---|---|
| Other Names | G-protein coupled receptor 15, Brother of Bonzo, BoB, GPR15 |
| Target/Specificity | This GPR15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-360 amino acids from the C-terminal region of human GPR15. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR15 |
|---|---|
| Function | G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol- calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in lymphoid tissues, including macrophages and peripheral blood mononuclear cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
GPR15 is a probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Blaak, H., et al. J. Virol. 79(3):1686-1700(2005)
Croitoru-Lamoury, J., et al. Glia 41(4):354-370(2003)
Maresca, M., et al. J. Biomed. Sci. 10(1):156-166(2003)
Clayton, F., et al. Am. J. Pathol. 159(5):1933-1939(2001)
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