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Mouse Oxsr1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6P9R2 |
| Other Accession | NP_598746.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58214 Da |
| Antigen Region | 94-121 aa |
| Gene ID | 108737 |
|---|---|
| Other Names | Serine/threonine-protein kinase OSR1, Oxidative stress-responsive 1 protein, Oxsr1 {ECO:0000312|MGI:MGI:1917378} |
| Target/Specificity | This Mouse Oxsr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-121 amino acids from the N-terminal region of mouse Oxsr1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Oxsr1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Oxsr1 {ECO:0000312|MGI:MGI:1917378} |
|---|---|
| Function | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:17488636, PubMed:19633012, PubMed:21486947). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:12386165, PubMed:16382158, PubMed:17488636, PubMed:19633012, PubMed:21486947). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16382158, PubMed:21972418). Phosphorylation of Na- K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16382158). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:17488636, PubMed:19633012). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:21972418). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (By similarity). Phosphorylates RELL1, RELL2, RELT and PAK1 (By similarity). Phosphorylates PLSCR1 in the presence of RELT (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O95747}. |
| Tissue Location | Ubiquitously expressed in all tissues examined, except thymus. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Oxsr1 regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.
References
Hengl, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(13):6052-6057(2010)
Geng, Y., et al. J. Biol. Chem. 284(21):14020-14028(2009)
Vallon, V. Kidney Int. 74(11):1373-1375(2008)
Chiga, M., et al. Kidney Int. 74(11):1403-1409(2008)
Gagnon, K.B., et al. Mol. Cell. Biol. 26(2):689-698(2006)
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$ 365.00
$ 140.00
Cat# AP14158a
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