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Mouse Pxk Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8BX57 |
| Other Accession | Q4FZZ1, Q7Z7A4, NP_663433.2, NP_840063.1, Q32NE9 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65231 Da |
| Antigen Region | 164-193 aa |
| Gene ID | 218699 |
|---|---|
| Other Names | PX domain-containing protein kinase-like protein, Modulator of Na, K-ATPase, MONaKA, Pxk {ECO:0000312|MGI:MGI:1289230} |
| Target/Specificity | This Mouse Pxk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the Central region of mouse Pxk. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Pxk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Pxk {ECO:0000312|MGI:MGI:1289230} |
|---|---|
| Function | Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane |
| Tissue Location | Isoform 1 is present in all tissues examined. Isoform 2 is found in all tissues except skeletal muscle and very low levels in spleen. Both isoforms are widely expressed throughout the nervous system however levels of isoform 2 are higher in purified hippocampal and cortical neurons whereas glial cells express more isoform 1 than isoform 2. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Pxk binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
References
Mao, H., et al. J. Neurosci. 25(35):7934-7943(2005)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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