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STC2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - STC2 Antibody (C-term) AP14314b
    STC2 Antibody (C-term) (Cat. #AP14314b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the STC2 antibody detected the STC2 protein (arrow).
    detail
  • IHC-P - STC2 Antibody (C-term) AP14314b
    STC2 Antibody (C-term) (Cat. #AP14314b)immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of STC2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession O76061
Other Accession Q9R0K8, O88452, NP_003705.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33249 Da
Antigen Region 273-302 aa
Additional Information
Gene ID 8614
Other Names Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2
Target/Specificity This STC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the C-terminal region of human STC2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STC2
Function Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Cellular Location Secreted.
Tissue Location Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes
Research Areas
Citations (0)
citation

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Background

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

References

Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010)
Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009)
Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009)
Tamura, K., et al. Cancer Sci. 100(5):914-919(2009)

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$ 182.50
$ 70.00
Cat# AP14314b
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