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ZIC4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N9L1 |
| Other Accession | NP_115529.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36567 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 84107 |
|---|---|
| Other Names | Zinc finger protein ZIC 4, Zinc finger protein of the cerebellum 4, ZIC4 |
| Target/Specificity | This ZIC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ZIC4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZIC4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZIC4 |
|---|---|
| Function | Binds to DNA. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene.
References
Grinberg, I., et al. Clin. Genet. 67(4):290-296(2005)
Jaster, J.H. Neurology 63 (7), 1339 (2004) :
Grinberg, I., et al. Nat. Genet. 36(10):1053-1055(2004)
Ohtsuka, M., et al. Genomics 83(6):1063-1071(2004)
Bataller, L., et al. Neurology 62(5):778-782(2004)
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