Mouse Map4k4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P97820 |
Other Accession | NP_032722.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 140602 Da |
Antigen Region | 506-534 aa |
Gene ID | 26921 |
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Other Names | Mitogen-activated protein kinase kinase kinase kinase 4, HPK/GCK-like kinase HGK, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, Nck-interacting kinase, Map4k4, Nik |
Target/Specificity | This Mouse Map4k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from the Central region of mouse Map4k4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Map4k4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Map4k4 |
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Synonyms | Nik |
Function | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Appears to be ubiquitous, expressed in all tissue types examined. Highest levels observed in heart and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway.
References
Maruyama, T., et al. J. Bone Miner. Res. 25(5):1058-1067(2010)
Guntur, K.V., et al. J. Biol. Chem. 285(9):6595-6603(2010)
Aouadi, M., et al. Nature 458(7242):1180-1184(2009)
Wittwer, T., et al. Biochem. Biophys. Res. Commun. 371(2):294-297(2008)
Tesz, G.J., et al. J. Biol. Chem. 282(27):19302-19312(2007)
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