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Mouse Yes1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Yes1 Antibody (N-term) AP14473A
    Mouse Yes1 Antibody (N-term) (Cat. #AP14473a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the Yes1 antibody detected the Yes1 protein (arrow).
    detail
  • WB - Mouse Yes1 Antibody (N-term) AP14473A
    Western blot analysis of Yes1 (arrow) using rabbit polyclonal Mouse Yes1 Antibody (N-term) (Cat. #AP14473a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Yes1 gene.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q04736
Other Accession F1LM93, NP_033561.1
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 60630 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 22612
Other Names Tyrosine-protein kinase Yes, Proto-oncogene c-Yes, p61-Yes, Yes1, Yes
Target/Specificity This Mouse Yes1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of mouse Yes1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Yes1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Yes1
Synonyms Yes
Function Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622).
Cellular Location Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.
Research Areas
Citations (0)
citation

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References

Zheng, Y., et al. Mol. Cell. Biol. 30(17):4280-4292(2010)
Slanina, H., et al. Infect. Immun. 78(5):1905-1914(2010)
Abrami, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(4):1420-1424(2010)
Chen, S.C., et al. Am. J. Physiol., Cell Physiol. 297 (1), C133-C139 (2009) :
Kao, T.J., et al. J. Neurosci. 29(17):5690-5700(2009)

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$ 365.00
$ 140.00
Cat# AP14473A
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