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CNGA2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q16280 |
| Other Accession | Q03041, NP_005131.1 |
| Reactivity | Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76048 Da |
| Antigen Region | 190-218 aa |
| Gene ID | 1260 |
|---|---|
| Other Names | Cyclic nucleotide-gated olfactory channel, Cyclic nucleotide-gated cation channel 2, Cyclic nucleotide-gated channel alpha-2, CNG channel alpha-2, CNG-2, CNG2, CNGA2, CNCA, CNCA1, CNCG2 |
| Target/Specificity | This CNGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-218 amino acids from the N-terminal region of human CNGA2. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNGA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNGA2 {ECO:0000303|PubMed:11764791, ECO:0000312|HGNC:HGNC:2149} |
|---|---|
| Function | Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)- dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Cellular Location | Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q00195}; Multi-pass membrane protein |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation.
References
Qu, W., et al. J. Gen. Physiol. 127(4):375-389(2006)
Hofmann, F., et al. Pharmacol. Rev. 57(4):455-462(2005)
Yoo, D., et al. J. Biol. Chem. 279(8):6863-6873(2004)
Cheng, K.T., et al. Histochem. Cell Biol. 120(6):475-481(2003)
Trudeau, M.C., et al. J. Biol. Chem. 278(21):18705-18708(2003)
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