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FST Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FST Antibody (C-term) AP14597B
    FST Antibody (C-term) (Cat. #AP14597b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FST antibody detected the FST protein (arrow).
    detail
  • IHC-P - FST Antibody (C-term) AP14597B
    FST Antibody (C-term) (AP14597b)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FST Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P19883
Other Accession P10669, Q90844, P50291, NP_006341.1, NP_037541.1, O62650, P31514
Reactivity Human
Predicted Bovine, Chicken, Horse, Pig, Sheep
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38007 Da
Antigen Region 312-340 aa
Additional Information
Gene ID 10468
Other Names Follistatin, FS, Activin-binding protein, FST
Target/Specificity This FST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 amino acids from the C-terminal region of human FST.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFST Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FST (HGNC:3971)
Function Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Cellular Location Secreted.
Tissue Location Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).
Research Areas
Citations (0)
citation

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Background

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq].

References

Chen, M.J., et al. Hum. Reprod. 25(3):779-785(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Fajardo, M., et al. Clin. Orthop. Relat. Res. 467(12):3071-3078(2009)
Bloise, E., et al. BMC Cancer 9, 320 (2009) :

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$ 182.50
$ 70.00
Cat# AP14597B
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