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PLD2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 4
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14939 |
| Other Accession | Q0V8L6, NP_002654.3 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 105987 Da |
| Antigen Region | 10-39 aa |
| Gene ID | 5338 |
|---|---|
| Other Names | Phospholipase D2, PLD 2, hPLD2, Choline phosphatase 2, PLD1C, Phosphatidylcholine-hydrolyzing phospholipase D2, PLD2 |
| Target/Specificity | This PLD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human PLD2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLD2 (HGNC:9068) |
|---|---|
| Function | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P97813}; Lipid-anchor {ECO:0000250|UniProtKB:P97813} |
| Tissue Location | Ubiquitous.. |
Provided below are standard protocols that you may find useful for product applications.
Background
Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM].
References
Chae, Y.C., et al. Mol. Cell. Biol. 30(21):5086-5098(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Knapek, K., et al. Mol. Cell. Biol. 30(18):4492-4506(2010)
Tabatabaian, F., et al. J. Biol. Chem. 285(25):18991-19001(2010)
Kang, D.W., et al. PLoS ONE 5 (8), E12109 (2010) :
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