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CACNB2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q08289 |
| Other Accession | Q8VGC3, P54288, Q8CC27, Q9MZL5, NP_963864.1, NP_963890.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 73581 Da |
| Antigen Region | 232-261 aa |
| Gene ID | 783 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB |
| Target/Specificity | This CACNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the Central region of human CACNB2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CACNB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACNB2 |
|---|---|
| Synonyms | CACNLB2, MYSB |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). |
| Cellular Location | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side |
| Tissue Location | Expressed in all tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a subunit of a voltage-dependent calcium channel protein which is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome which is an autoimmune disorder. Mutations in this gene are associated with Brugada symdrome. Alternatively spliced variants have been identified for this gene.
References
Burashnikov, E., et al. Heart Rhythm (2010) In press :
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)
Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)
Lee, M.T., et al. Mol. Psychiatry (2010) In press :
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