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SND1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7KZF4 |
| Other Accession | Q66X93, Q78PY7, Q7ZT42, Q863B3, NP_055205.2 |
| Reactivity | Human |
| Predicted | Bovine, Zebrafish, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101997 Da |
| Antigen Region | 449-478 aa |
| Gene ID | 27044 |
|---|---|
| Other Names | Staphylococcal nuclease domain-containing protein 1, 100 kDa coactivator, EBNA2 coactivator p100, Tudor domain-containing protein 11, p100 co-activator, SND1, TDRD11 |
| Target/Specificity | This SND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 449-478 amino acids from the Central region of human SND1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SND1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SND1 |
|---|---|
| Synonyms | TDRD11 |
| Function | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Melanosome Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) |
| Tissue Location | Ubiquitously expressed. |
Provided below are standard protocols that you may find useful for product applications.
Background
SND1 functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)
Gao, X., et al. FEBS Lett. 584(16):3525-3532(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
dit Frey, N.F., et al. Plant Cell 22(5):1575-1591(2010)
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