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NGDN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NEJ9 |
| Other Accession | NP_056329.1, NP_001036100.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35894 Da |
| Antigen Region | 136-165 aa |
| Gene ID | 25983 |
|---|---|
| Other Names | Neuroguidin, Centromere accumulated nuclear protein 1, CANu1, EIF4E-binding protein, NGDN, C14orf120 |
| Target/Specificity | This NGDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human NGDN. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NGDN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NGDN (HGNC:20271) |
|---|---|
| Synonyms | C14orf120 |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9DB96}. Nucleus, nucleolus Chromosome, centromere. Cytoplasm {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DB96}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9DB96}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites {ECO:0000250|UniProtKB:Q9DB96} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).
References
Sihn, C.R., et al. Genes Cells 13(8):787-796(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jung, M.Y., et al. Mol. Cell. Biol. 26(11):4277-4287(2006)
Nousiainen, M., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5391-5396(2006)
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