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RGS5 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O15539 |
| Other Accession | NP_003608.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20946 Da |
| Antigen Region | 24-53 aa |
| Gene ID | 8490 |
|---|---|
| Other Names | Regulator of G-protein signaling 5, RGS5, RGS5 |
| Target/Specificity | This RGS5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human RGS5. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RGS5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RGS5 |
|---|---|
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity). |
| Cellular Location | [Isoform 1]: Cytoplasm. Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Li, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13818-13823(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xiao, B., et al. Clin. Chem. Lab. Med. 47(12):1483-1488(2009)
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