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Mouse Acvr2a Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P27038 |
| Other Accession | P38444, NP_031422.3 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57890 Da |
| Antigen Region | 22-49 aa |
| Gene ID | 11480 |
|---|---|
| Other Names | Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, Acvr2a, Acvr2 |
| Target/Specificity | This Mouse Acvr2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of mouse Acvr2a. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Acvr2a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Acvr2a {ECO:0000312|MGI:MGI:102806} |
|---|---|
| Synonyms | Acvr2 |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Brain, testis, intestine, liver and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
References
Perron, J.C., et al. PLoS ONE 4 (12), E8198 (2009) :
Morita, S., et al. PLoS ONE 4 (1), E4212 (2009) :
Kamiya, N., et al. Development 135(22):3801-3811(2008)
Xia, Y., et al. J. Biol. Chem. 282(25):18129-18140(2007)
Lee, Y.J., et al. Genesis 44(10):487-494(2006)
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