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PPP2R5A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15172 |
| Other Accession | Q6PD03, NP_006234.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56194 Da |
| Antigen Region | 418-446 aa |
| Gene ID | 5525 |
|---|---|
| Other Names | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PR61alpha, PP2A B subunit isoform R5-alpha, PPP2R5A |
| Target/Specificity | This PPP2R5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-446 amino acids from the C-terminal region of human PPP2R5A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPP2R5A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPP2R5A |
|---|---|
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Cellular Location | Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase |
| Tissue Location | Widely expressed with the highest expression in heart and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.
References
Flegg, C.P., et al. J. Biol. Chem. 285(24):18144-18154(2010)
Freeman, A.K., et al. Cell Cycle 9(4):736-747(2010)
Reece, K.M., et al. Biochem. Biophys. Res. Commun. 386(4):582-587(2009)
Li, H., et al. Mol. Cell. Biol. 29(3):919-928(2009)
Ruvolo, V.R., et al. J. Biol. Chem. 283(51):35474-35485(2008)
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