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ACTR1A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P61163 |
| Other Accession | P85515, P61164, Q4R6J9, NP_005727.1, F2Z5G5 |
| Reactivity | Mouse |
| Predicted | Monkey, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42614 Da |
| Antigen Region | 98-126 aa |
| Gene ID | 10121 |
|---|---|
| Other Names | Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated actin homolog, ACTR1A, CTRN1 |
| Target/Specificity | This ACTR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the Central region of human ACTR1A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ACTR1A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACTR1A (HGNC:167) |
|---|---|
| Synonyms | CTRN1 |
| Function | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85515}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.
References
Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3521-3526(2008)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)
Carew, J.A., et al. J. Thromb. Haemost. 1(6):1220-1227(2003)
Takahashi, M., et al. Mol. Biol. Cell 13(9):3235-3245(2002)
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