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SEC14L2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O76054 |
| Other Accession | Q99MS0, Q99J08, P58875, NP_036561.1, NP_203740.1 |
| Reactivity | Mouse |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46145 Da |
| Antigen Region | 41-69 aa |
| Gene ID | 23541 |
|---|---|
| Other Names | SEC14-like protein 2, Alpha-tocopherol-associated protein, TAP, hTAP, Squalene transfer protein, Supernatant protein factor, SPF, SEC14L2, C22orf6, KIAA1186, KIAA1658 |
| Target/Specificity | This SEC14L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human SEC14L2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC14L2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC14L2 |
|---|---|
| Synonyms | C22orf6, KIAA1186, KIAA1658 |
| Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha- tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol |
| Tissue Location | Widely expressed. Strong expression in liver, brain and prostate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
References
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Wang, X., et al. Cancer Invest. 27(10):971-977(2009)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Johnykutty, S., et al. Mod. Pathol. 22(6):770-775(2009)
Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)
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