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NR2C1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P13056 |
| Other Accession | Q95K90, A0JNE3, NP_001027458.1, NP_001120834.1 |
| Reactivity | Human |
| Predicted | Bovine, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67315 Da |
| Antigen Region | 516-545 aa |
| Gene ID | 7181 |
|---|---|
| Other Names | Nuclear receptor subfamily 2 group C member 1, Orphan nuclear receptor TR2, Testicular receptor 2, NR2C1, TR2 |
| Target/Specificity | This NR2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human NR2C1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NR2C1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NR2C1 |
|---|---|
| Synonyms | TR2 |
| Function | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Nucleus, PML body. Note=Recruited by HDAC3, after all- trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lin, Y.L., et al. Biochem. Biophys. Res. Commun. 350(2):430-436(2006)
Li, G., et al. Biochem. Biophys. Res. Commun. 310(2):384-390(2003)
Mu, X., et al. Prostate 57(2):129-133(2003)
Franco, P.J., et al. Mol. Endocrinol. 15(8):1318-1328(2001)
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