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SYNGR1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43759 |
| Other Accession | NP_663783.1, NP_004702.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25456 Da |
| Antigen Region | 154-183 aa |
| Gene ID | 9145 |
|---|---|
| Other Names | Synaptogyrin-1, SYNGR1 |
| Target/Specificity | This SYNGR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the C-terminal region of human SYNGR1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYNGR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYNGR1 (HGNC:11498) |
|---|---|
| Function | May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62876}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q62876}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
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Provided below are standard protocols that you may find useful for product applications.
Background
SYNGR1 is an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family.
References
Iatropoulos, P., et al. Psychiatr. Genet. 19(5):237-243(2009)
Wang, Y., et al. Psychiatry Res 169(2):167-168(2009)
Cheng, M.C., et al. J Psychiatr Res 41(12):1027-1031(2007)
Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
Verma, R., et al. J. Hum. Genet. 50(12):635-640(2005)
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