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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > FAM38B Antibody-(C-term)
FAM38B Antibody-(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H5I5 |
| Other Accession | Q8CD54, NP_071351.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 318064 Da |
| Antigen Region | 2575-2604 aa |
| Gene ID | 63895 |
|---|---|
| Other Names | Piezo-type mechanosensitive ion channel component 2, Protein FAM38B, PIEZO2, C18orf30, C18orf58, FAM38B |
| Target/Specificity | This FAM38B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2575-2604 amino acids of human FAM38B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FAM38B Antibody-(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIEZO2 (HGNC:26270) |
|---|---|
| Function | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and- latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8CD54}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CD54} |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons (Coste et al., 2010 [PubMed 20813920]).
References
Coste, B., et al. Science 330(6000):55-60(2010)
Brandenberger, R., et al. Nat. Biotechnol. 22(6):707-716(2004)
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$ 385.00
$ 150.00
Cat# AP16313b
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