EME2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | A4GXA9 |
Other Accession | NP_001010865.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 41178 Da |
Antigen Region | 249-278 aa |
Gene ID | 197342 |
---|---|
Other Names | Probable crossover junction endonuclease EME2, 3122-, EME2 |
Target/Specificity | This EME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-278 amino acids from the C-terminal region of human EME2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EME2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EME2 |
---|---|
Function | Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).
References
Ciccia, A., et al. Mol. Cell 25(3):331-343(2007)
Ciccia, A., et al. J. Biol. Chem. 278(27):25172-25178(2003)
Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)
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