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GUCA2B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16661 |
| Other Accession | NP_009033.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 12069 Da |
| Antigen Region | 69-97 aa |
| Gene ID | 2981 |
|---|---|
| Other Names | Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B |
| Target/Specificity | This GUCA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the C-terminal region of human GUCA2B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GUCA2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GUCA2B |
|---|---|
| Function | Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. |
| Cellular Location | Secreted. |
| Tissue Location | Stomach and intestine. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Uroguanylin and guanylin (GUCA2A; MIM 139392), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.
References
Yoshikawa, Y., et al. Hypertens. Res. 30(9):789-796(2007)
Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35(3):233-236(2007)
Sindic, A., et al. Kidney Int. 67(4):1420-1427(2005)
Maake, C., et al. Histochem. Cell Biol. 119(1):69-76(2003)
Sindice, A., et al. J. Biol. Chem. 277(20):17758-17764(2002)
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