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CNTROB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N137 |
| Other Accession | NP_444279.2. |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101253 Da |
| Antigen Region | 401-430 aa |
| Gene ID | 116840 |
|---|---|
| Other Names | Centrobin, Centrosomal BRCA2-interacting protein, LYST-interacting protein 8, CNTROB, LIP8 |
| Target/Specificity | This CNTROB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human CNTROB. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNTROB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNTROB |
|---|---|
| Synonyms | LIP8 |
| Function | Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Centriole-associated, asymmetrically localizes to the daughter centriole |
| Tissue Location | Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
CNTROB is a centrosomal protein that interacts with BRCA2 (MIM 600185) and is required for centriole duplication and cytokinesis (Zou et al., 2005 [PubMed 16275750]).[supplied by OMIM].
References
Lee, J., et al. J. Biol. Chem. 285(33):25476-25484(2010)
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Jeffery, J.M., et al. Oncogene 29(18):2649-2658(2010)
Song, L., et al. Cell. Signal. 22(5):857-864(2010)
Jeong, Y., et al. J. Cell. Sci. 120 (PT 12), 2106-2116 (2007) :
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