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ACTL7B Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ACTL7B Antibody (N-term) AP16511a
    ACTL7B Antibody (N-term) (Cat. #AP16511a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ACTL7B antibody detected the ACTL7B protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y614
Other Accession NP_006677.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 45234 Da
Antigen Region 69-97 aa
Additional Information
Gene ID 10880
Other Names Actin-like protein 7B, Actin-like-7-beta, ACTL7B
Target/Specificity This ACTL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the N-terminal region of human ACTL7B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACTL7B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACTL7B
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Detected only in the testis and, to a lesser extent, in the prostate.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.

References

Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Hisano, M., et al. Nucleic Acids Res. 31(16):4797-4804(2003)
Chadwick, B.P., et al. Genomics 58(3):302-309(1999)
Schafer, D.A., et al. Annu. Rev. Cell Dev. Biol. 15, 341-363 (1999) :

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$ 182.50
$ 70.00
Cat# AP16511a
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