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RIT2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99578 |
| Other Accession | Q5BJQ5, P70425, NP_002921.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24668 Da |
| Antigen Region | 41-69 aa |
| Gene ID | 6014 |
|---|---|
| Other Names | GTP-binding protein Rit2, Ras-like protein expressed in neurons, Ras-like without CAAX protein 2, RIT2, RIN, ROC2 |
| Target/Specificity | This RIT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human RIT2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RIT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RIT2 |
|---|---|
| Synonyms | RIN, ROC2 |
| Function | Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. |
| Cellular Location | Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). |
| Tissue Location | Neuron-specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Glessner, J.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10584-10589(2010)
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Sonuga-Barke, E.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1359-1368 (2008) :
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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