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TTL Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NG68 |
| Other Accession | Q9QXJ0, P38160, P38585, P38584, NP_714923.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43212 Da |
| Antigen Region | 232-263 aa |
| Gene ID | 150465 |
|---|---|
| Other Names | Tubulin--tyrosine ligase, TTL, TTL |
| Target/Specificity | This TTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-263 amino acids from the C-terminal region of human TTL. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TTL |
|---|---|
| Function | Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).
References
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Erck, C., et al. Cytogenet. Genome Res. 101(1):47-53(2003)
Mialhe, A., et al. Cancer Res. 61(13):5024-5027(2001)
Ersfeld, K., et al. J. Cell Biol. 120(3):725-732(1993)
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