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CPEB1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZB8 |
| Other Accession | P0C279, P70166, Q9YGX5, Q52KN7, Q91572, NP_001073001.1, NP_001073002.1 |
| Reactivity | Human |
| Predicted | Xenopus, Zebrafish, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62595 Da |
| Antigen Region | 447-475 aa |
| Gene ID | 64506 |
|---|---|
| Other Names | Cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, h-CEBP, hCPEB-1, CPEB1, CPEB |
| Target/Specificity | This CPEB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 447-475 amino acids from the C-terminal region of human CPEB1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPEB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPEB1 |
|---|---|
| Synonyms | CPEB |
| Function | Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'- UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195). |
| Cellular Location | Cytoplasm. Nucleus Cytoplasm, P-body. Cytoplasmic granule. Synapse. Membrane. Postsynaptic density. Cell projection, dendrite Note=Continuously shuttling between nucleus and cytoplasm (PubMed:18923137). Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity) Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity) Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:18923137} |
| Tissue Location | Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Glahder, J.A., et al. Virus Res. 149(2):217-223(2010)
Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)
Hansen, C.N., et al. APMIS 117(1):53-59(2009)
Ernoult-Lange, M., et al. Mol. Biol. Cell 20(1):176-187(2009)
Burns, D.M., et al. Genes Dev. 22(24):3449-3460(2008)
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