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ZNF263 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14978 |
| Other Accession | NP_005732.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77299 Da |
| Antigen Region | 318-346 aa |
| Gene ID | 10127 |
|---|---|
| Other Names | Zinc finger protein 263, Zinc finger protein FPM315, Zinc finger protein with KRAB and SCAN domains 12, ZNF263, FPM315, ZKSCAN12 |
| Target/Specificity | This ZNF263 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-346 amino acids from the Central region of human ZNF263. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF263 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF263 (HGNC:13056) |
|---|---|
| Function | Transcription factor that binds to the consensus sequence 5'- TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
ZNF263 might play an important role in basic cellular processes as a transcriptional repressor.
References
Frietze, S., et al. J. Biol. Chem. 285(2):1393-1403(2010)
Martin, J., et al. Nature 432(7020):988-994(2004)
Yokoyama, M., et al. Biochim. Biophys. Acta 1353(1):13-17(1997)
Okubo, K., et al. Genomics 30(2):178-186(1995)
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