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TGFBI Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q15582 |
| Other Accession | Q95215, O11780, P82198, NP_000349.1, P55906 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Pig, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74681 Da |
| Antigen Region | 106-135 aa |
| Gene ID | 7045 |
|---|---|
| Other Names | Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Kerato-epithelin, RGD-containing collagen-associated protein, RGD-CAP, TGFBI, BIGH3 |
| Target/Specificity | This TGFBI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human TGFBI. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TGFBI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TGFBI |
|---|---|
| Synonyms | BIGH3 |
| Function | Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix Note=May be associated both with microfibrils and with the cell surface (PubMed:8077289). |
| Tissue Location | Highly expressed in the corneal epithelium (PubMed:27609313, PubMed:8077289). Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:8077289) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Edelstein, S.L., et al. Cornea 29(6):698-700(2010)
Romero, P., et al. Mol. Vis. 16, 1601-1609 (2010) :
Paliwal, P., et al. Mol. Vis. 16, 1429-1438 (2010) :
Yang, J., et al. Mol. Vis. 16, 1186-1193 (2010) :
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